Located in the heart of the Texas Panhandle off Interstate 40, our Quality Inn^® Amarillo hotel provides easy access to a range of experiences under a big west Texas sky — from hiking in the Palo Duro Canyon to exploring Historic Route 66. Our affordable hotel is surrounded by top-notch medical centers — Baptist St. Anthony’s Hospital, Northwest Texas Hospital and the Veterans Hospital — and the Amarillo Convention Center, which makes us ideal for business or leisure travel.